If you're using another software for managing mobile phones, it is recommended to shut it down before attempting to establish a connection through MOBILedit Phone Manager.
If there is such software running, you will be notified by the Connection Wizard.
This dialogue can help you to close the concurrent application. It is recommended to close the application the usual way to prevent a data loss. If you are sure, that the application doesn't conflict with MOBILedit Phone Manager, you can ignore this warning and carry on by clicking the Next button (advanced users).
Microsoft Active Sync / Sync Center does not restrain MOBILedit Phone Manager from working properly. On the contrary, these are required for connection of Windows Mobile-based smartphones.
iTunes has to be installed in order to connect an iPhone / iPod (or any other Apple device) because of the required drivers. However, it should not be running when using MOBILedit Phone Manager. To learn how to connect an iPhone, please proceed to the article Connecting an iPhone.